The effects of acetazolamide on the human electroretinogram.
نویسندگان
چکیده
The effects of acetazolamied on the cerebral circulation and metabolism was previously shown to be due to a raised PCO2 in brain tissue. The effects of the drug on the human electroretinogram (ERG) are investigated in fifteen human volunteer subjects. A significant increase in the b-wave was found. A similitude with the mechanism of acetazolamide administration in brain and retinal tissue seems to be a possible explanation.
منابع مشابه
The effects of acetazolamide on visual function in retinitis pigmentosa.
PURPOSE To study the effects of acetazolamide on central and peripheral visual function in patients with retinitis pigmentosa (RP) who showed no evidence of macular edema. METHODS Thirteen patients with retinitis pigmentosa participated in a preliminary study. Measures of central and peripheral visual function were obtained before and after an 8 wk period on acetazolamide. An additional 10 pa...
متن کاملThe effects of acetazolamide on the electroretinographic responses in rats.
PURPOSE To study the mechanisms and sites of action of the carbonic anhydrase inhibitor, acetazolamide (AZM), on the rod- and cone-mediated electroretinogram (ERG) of the dark-adapted rat. METHODS After a within-subjects design, ERG responses to brief, full-field flashes were recorded from adult (60 to 90 days old) albino rats, with and without AZM (5 mg/100 g, intraperitoneally). Flickering ...
متن کاملAcetazolamide acts directly on the human skeletal muscle chloride channel.
Acetazolamide, a carbonic anhydrase inhibitor, is used empirically in neuromuscular diseases with episodic ataxia, weakness, and myotonia, although not all of the mechanisms responsible for its therapeutic effects are understood. To elucidate whether acetazolamide acts directly on the human skeletal muscle voltage-gated chloride channel (ClC-1), which is associated with myotonia, we evaluated t...
متن کاملInvestigating the frequency characteristics of the electroretinogram signal in patients with central retinal vein occlusion
Background: Central retinal vein occlusion (CRVO) is the second most common retinal vascular disorder after diabetic retinopathy. In this study, we tried to examine the potentials of time-frequency methods for differentiating the eyes with CRVO. Materials and methods: Twenty patients with unilateral CRVO were included in this study. Their contralateral normal eyes were considered as the control...
متن کاملAcetazolamide potentiates the afferent drive to prefrontal cortex in vivo
The knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide - a carbonic anhydrase inhibitor - has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Investigative ophthalmology
دوره 14 12 شماره
صفحات -
تاریخ انتشار 1975